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Capítulo 26

O Citoesqueleto II: Microtúbulos e Filamentos Intermediários

Microtúbulos
Microtúbulos
Microtubules are the thickest cytoskeletal filaments with a diameter of 25 nm. In prokaryotic organisms, microtubules are commonly found in locomotory ...
Instabilidade do Microtúbulo
Instabilidade do Microtúbulo
Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound ...
Formação de Microtúbulos
Formação de Microtúbulos
Microtubules are dynamic structures that undergo continuous assembly and disassembly. They originate from specialized multi-protein complexes known as ...
Proteínas Associadas a Microtúbulos (MAPs)
Proteínas Associadas a Microtúbulos (MAPs)
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are ...
Desestabilização dos Microtúbulos
Desestabilização dos Microtúbulos
The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at ...
Proteínas Motoras Associadas a  Microtúbulos
Proteínas Motoras Associadas a Microtúbulos
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they ...
O Movimento de Organelas e Vesículas
O Movimento de Organelas e Vesículas
In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These ...
Montagem de Estruturas Complexas de Microtúbulos
Montagem de Estruturas Complexas de Microtúbulos
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular ...
Microtúbulos na Motilidade Celular
Microtúbulos na Motilidade Celular
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form ...
Mecanismo do Movimento Ciliar
Mecanismo do Movimento Ciliar
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible ...
Microtúbulos na Sinalização
Microtúbulos na Sinalização
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like ...
Drogas que Estabilizam Microtúbulos
Drogas que Estabilizam Microtúbulos
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the ...
Drogas que Desestabilizam Microtúbulos
Drogas que Desestabilizam Microtúbulos
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that ...
A Estrutura dos Filamentos Intermediários
A Estrutura dos Filamentos Intermediários
The intermediate filaments are one of three widely studied cytoskeletal filaments. They are so named as their diameter (10 nm) is in between that of ...
Tipos de Filamentos Intermediários
Tipos de Filamentos Intermediários
The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and ...
Formação de Filamentos Intermediários
Formação de Filamentos Intermediários
Intermediate filaments are cytoskeletal proteins with higher tensile strength and flexibility than microfilaments and microtubules. Unlike the other two ...
Desmontagem de Filamentos Intermediários
Desmontagem de Filamentos Intermediários
Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to ...
Septinas
Septinas
Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. ...
O papel das Septinas
O papel das Septinas
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate ...
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