Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo
21.2K Views
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09:44 min
•
June 2nd, 2019
DOI :
June 2nd, 2019
•Joseph R. Patterson1, Nicole K. Polinski2, Megan F. Duffy1,3, Christopher J. Kemp1, Kelvin C. Luk4, Laura A. Volpicelli-Daley5, Nicholas M. Kanaan1, Caryl E. Sortwell1,3,6
1Department of Translational Science and Molecular Medicine, Michigan State University, 2The Michael J. Fox Foundation for Parkinson's Research, 3Neuroscience Program, Michigan State University, 4Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 5Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 6Mercy Health Hauenstein Neuroscience Medical Center
Chapters in this video
0:04
Title
1:13
Formation of α-synuclein Preformed Fibrils from Monomers
2:20
Sonication of α-synuclein Preformed Fibrils
4:37
Preparation of Custom Glass Needle Syringes for Stereotactic Injections
7:18
Results: Analysis of the Generated Alpha-Synuclein Preformed Fibrils
9:22
Conclusion
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