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Core - Pharmacokinetics and Pharmacodynamics

    Chapter 8

    Nonlinear Pharmacokinetics

    8.1 : Nonlinear Pharmacokinetics: Overview01:19

    8.1 : Nonlinear Pharmacokinetics: Overview

    Nonlinear pharmacokinetics, or dose-dependent kinetics, manifests when certain drugs deviate from linear behavior at higher doses, not to follow ...

    309 views
    8.2 : Nonlinear Pharmacokinetics: Causes of Nonlinearity01:22

    8.2 : Nonlinear Pharmacokinetics: Causes of Nonlinearity

    Various factors contribute to nonlinearity in drug pharmacokinetics. Nonlinearity in drug absorption may result from rate-limited solubility, ...

    147 views
    8.3 : Nonlinear Pharmacokinetics: Michaelis-Menten Equation01:18

    8.3 : Nonlinear Pharmacokinetics: Michaelis-Menten Equation

    The Michaelis-Menten equation describes capacity-limited kinetics in drug metabolism. It determines the rate of decline of drug concentration over time, ...

    259 views
    8.4 : Determination of Michaelis Constant and Maximum Elimination Rate01:20

    8.4 : Determination of Michaelis Constant and Maximum Elimination Rate

    The Michaelis-Menten equation parameters–Michaelis constant, KM, and the maximum process rate, Vmax – are estimated post-drug administration. ...

    73 views
    8.5 : Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection00:59

    8.5 : Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection

    In capacity-limited pharmacokinetics, drug elimination is influenced by Vmax and KM. Following an IV bolus, Dt, the amount of drug in the body at any ...

    49 views
    8.6 : Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview01:25

    8.6 : Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview

    Drug administration through various routes results in mixed drug elimination, involving both nonlinear and linear processes. The metabolism of drugs ...

    53 views
    8.7 : Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

    8.7 : Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

    Drugs administered through different administration routes follow nonlinear elimination. Consider a drug administered through a constant IV infusion, ...

    55 views
    8.8 : Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

    8.8 : Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

    Drug elimination half-life and clearance vary with dosage or concentration in nonlinear kinetics. The elimination half-life is influenced by the ...

    103 views
    8.9 : Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

    8.9 : Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

    Circadian rhythms influence cyclic changes in plasma drug concentrations through regular fluctuations in physiological functions. Standard circadian ...

    48 views
    8.10 : Chronopharmacokinetics: Time-Dependent Pharmacokinetics01:20

    8.10 : Chronopharmacokinetics: Time-Dependent Pharmacokinetics

    Chronopharmacokinetics studies the temporal change in drug absorption and elimination, whether cyclical or noncyclical. Cyclic changes occur over constant ...

    106 views
    8.11 : Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding01:22

    8.11 : Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding

    For drugs that follow nonlinear pharmacokinetics, the absorption, distribution, and elimination processes may potentially saturate. A saturable pathway ...

    138 views
    8.12 : Nonlinear Pharmacokinetics: Role of Transporters01:27

    8.12 : Nonlinear Pharmacokinetics: Role of Transporters

    Drug kinetics, under nonlinear changes influenced by transporter proteins, are pivotal in drug distribution. These cellular transporters in cells modulate ...

    40 views
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