A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
4.1K Views
•
07:40 min
•
May 27th, 2021
DOI :
May 27th, 2021
•Chapters in this video
0:04
Introduction
1:03
Retrieving Synthetic Lethal Gene Pairs
1:48
Translating Synthetic Lethal Gene Pairs to Human Orthologs
3:20
Mapping Synthetic Lethal Interaction Partners to Drugs
4:28
Establish the Set of Currently Tested Drug Combinations in Clinical Trials
4:45
Testing Proposed Drug Combinations In Vitro
5:28
Results: Proposed Novel Drug Combinations for Ovarian and Breast Cancer
6:37
Conclusion
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