biology

Biology

cancer research

Cancer Research

biological techniques

Biological Techniques

immunology

Immunology

neuroscience

Neuroscience

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jove encyclopedia of experiments

JoVE Encyclopedia of Experiments

Online video encyclopedias of advanced research experiments for scientists in academia and biotech

Research

neuronal culture techniques

This collection features a variety of neuronal culture techniques, ranging from basic neuron cultures to advanced protocols for generating neural progenitors. It covers specific neuron cultures that employ three-dimensional scaffolds or microfluidics, and differentiation into brain organoids and networks. Techniques also encompass co-cultures to study neuron-glia interactions and synapse formation, among other approaches for exploring neuronal behavior and neurogenesis in vitro.

Neuronal Culture Techniques

neurophysiology

This collection presents methodologies for studying neural function and behavior. It features direct measurement techniques for recording electrical activities from neurons in diverse settings, and optical techniques for visualizing dynamic neuronal processes, tracking real-time changes, and examining spatial relationships within neural circuits. Additionally, it provides various stimulation methods using electrical, magnetic, and optogenetic tools to explore and modulate neural circuit responsiveness.

Neurophysiology

neuroimaging

This collection offers advanced methodologies for investigating brain structure, functional connectivity, and molecular dynamics in the nervous system. Focusing on in vitro and in vivo models, advanced imaging, and analytical techniques, these protocols equip researchers with innovative tools to study neural activity and pathologies across diverse areas.

Neuroimaging

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neuropathology

This collection offers advanced methodologies for investigating molecular mechanisms, structural changes, and functional disruptions in nervous system disorders. Focusing on in vitro and in vivo models, advanced imaging, and molecular analyses, these protocols equip researchers with innovative tools to study brain and neural pathologies across diverse areas.

Neuropathology

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structural & functional brain imaging

Structural & Functional Brain Imaging

synaptic & cellular imaging

Synaptic & Cellular Imaging

neurovascular & blood flow imaging

Neurovascular & Blood Flow Imaging

neurodegeneration & disease monitoring

Neurodegeneration & Disease Monitoring

developmental & regenerative neuroimaging

Developmental & Regenerative Neuroimaging

live imaging & in vivo tracking

Live Imaging & In Vivo Tracking

advanced microscopy & imaging technologies

Advanced Microscopy & Imaging Technologies

imaging hippocampal neuronal activation in mouse brain sections

imaging-hippocampal-neuronal-activation-in-mouse-brain-sections

Imaging Hippocampal Neuronal Activation In Mouse Brain Sections

Source: Provenzano, G., et al.&#160;Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of ...

transmission electron microscopic imaging of synaptic vesicle endocytosis in mouse hippocampal neurons 

transmission-electron-microscopic-imaging-synaptic-vesicle

Transmission Electron Microscopic Imaging of Synaptic Vesicle Endocytosis in Mouse Hippocampal Neurons 

Source: Villarreal, S., et. al., Measuring Synaptic Vesicle Endocytosis in Cultured Hippocampal Neurons. J. Vis. Exp. (2017)This video demonstrates the ...

immunofluorescence microscopy of neural cells differentiated from peripheral blood-derived cells 

immunofluorescence-microscopy-neural-cells-differentiated-from

Immunofluorescence Microscopy of Neural Cells Differentiated from Peripheral Blood-Derived Cells 

Source: Becker-Koji&#263;, Z. A., et. al., GM-Free Generation of Blood-Derived Neuronal Cells. J. Vis. Exp. (2021)The video demonstrates a protocol for ...

imaging intracellular atp dynamics using fret-based sensors in an organotypic mouse hippocampal slice

imaging-intracellular-atp-dynamics-using-fret-based-sensors-an

Imaging Intracellular ATP Dynamics Using FRET-Based Sensors in an Organotypic Mouse Hippocampal Slice

Source: Lerchundi, R., et. al. Imaging of Intracellular ATP in Organotypic Tissue Slices of the Mouse Brain using the FRET-based Sensor ATeam1.03YEMK. J. ...

microscopic analysis of synapses in mouse hippocampal slices using immunofluorescence

microscopic-analysis-synapses-mouse-hippocampal-slices-using

Microscopic Analysis of Synapses in Mouse Hippocampal Slices Using Immunofluorescence

Source: McLeod, F., et al. Evaluation of Synapse Density in Hippocampal Rodent Brain Slices. J. Vis. Exp. (2017).This video demonstrates a method for ...

 phase contrast magnetic resonance imaging to assess blood flow in the arteries of a rat

phase-contrast-magnetic-resonance-imaging-to-assess-blood-flow

 Phase Contrast Magnetic Resonance Imaging to Assess Blood Flow in the Arteries of a Rat

Source: Chiu, S., et al. Phase Contrast Magnetic Resonance Imaging in the Rat Common Carotid Artery. J. Vis. Exp. (2018).This video demonstrates phase ...

bioluminescence imaging of neuroinflammation in a transgenic mouse

bioluminescence-imaging-of-neuroinflammation-in-a-transgenic-mouse

Bioluminescence Imaging of Neuroinflammation in a Transgenic Mouse

Source: Breid, S., et. al. Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils. J. ...

analyzing amyloid structures in a tissue section using fluorescence lifetime imaging microscopy

analyzing-amyloid-structures-tissue-section-using-fluorescence

Analyzing Amyloid Structures in a Tissue Section Using Fluorescence Lifetime Imaging Microscopy

Source: Nystr&#246;m, S., et al.,&#160;Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy ...

ultrastructural analysis of a mouse brain section using transmission electron microscopy

ultrastructural-analysis-mouse-brain-section-using-transmission

Ultrastructural Analysis of a Mouse Brain Section Using Transmission Electron Microscopy

Source: Lutz, D., et.al. Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal ...

retrograde labeling of <i>drosophila</i> motor neurons using fluorescent lipophilic dyes

retrograde-labeling-drosophila-motor-neurons-using-fluorescent

Retrograde Labeling of <i>Drosophila</i> Motor Neurons Using Fluorescent Lipophilic Dyes

Source: Inal, M. A. et. al., Retrograde Tracing of Drosophila Embryonic Motor Neurons Using Lipophilic Fluorescent Dyes. J. Vis. Exp. (2020)This video ...

confocal imaging of mitochondrial movement within oligodendrocytes in organotypic brain slice cultures

confocal-imaging-mitochondrial-movement-within-oligodendrocytes

Confocal Imaging of Mitochondrial Movement within Oligodendrocytes in Organotypic Brain Slice Cultures

Source: Kennedy, L. H., et. al. Visualization and Live Imaging of Oligodendrocyte Organelles in Organotypic Brain Slices Using Adeno-associated Virus and ...

two-photon microscopy for studying microglial process attraction toward a compound in a mouse brain slice

two-photon-microscopy-for-studying-microglial-process-attraction

Two-Photon Microscopy for Studying Microglial Process Attraction Toward a Compound in a Mouse Brain Slice

Source: Etienne, F. et al. Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices.&#160;J. Vis. Exp. ...

imaging glut4 protein trafficking in mouse primary hypothalamic neurons using deconvolution microscopy

imaging-glut4-protein-trafficking-mouse-primary-hypothalamic-neurons

Imaging GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Source: Changou, C. A., et. al. Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy. J. Vis. ...

two-photon in vivo imaging of the mouse retina

two-photon-in-vivo-imaging-of-the-mouse-retina

Two-Photon In Vivo Imaging of the Mouse Retina

Source: Wang, Z., et al.&#160;Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina. J. Vis. Exp.&#160;(2021).This video demonstrates a technique ...

fluorescence imaging of neuro-immune dynamics using a skull implant

fluorescence-imaging-of-neuro-immune-dynamics-using-a-skull-implant

Fluorescence Imaging of Neuro-Immune Dynamics Using a Skull Implant

Source:&#160; Bisht, K., et al. Precise brain mapping to perform repetitive in vivo imaging of neuro-immune dynamics in mice. J. Vis. Exp. (2020)This ...

microscopic imaging of neurons in a mouse brain section using golgi-cox metallic staining

microscopic-imaging-neurons-mouse-brain-section-using-golgi-cox

Microscopic Imaging of Neurons in a Mouse Brain Section Using Golgi-Cox Metallic Staining

Source: Louth, E. L.,&#160; et al. Imaging neurons within thick brain sections using the Golgi-Cox method. J. Vis. Exp. (2017)This video demonstrates ...

Encyclopedia Of Experiments - neuroscience