Andrew E. Arrant

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.

Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice.

Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration.

Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.

Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.

Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.

Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.

Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusions.

Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.

Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients.

Delivering progranulin to neuronal lysosomes protects against excitotoxicity.

Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations.

Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia.

Regulation of extracellular progranulin in medial prefrontal cortex.

Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice.

Increased levels of extracellular matrix proteins associated with extracellular vesicles from brains of aged mice.