Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis

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3.9K Views

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08:17 min

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February 23rd, 2024

DOI :

10.3791/65738-v

February 23rd, 2024

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Carmen C. Ucciferri¹, Annette Gower², Nuria Alvarez-Sanchez¹^,², Heather Whetstone³, Valeria Ramaglia¹, Jennifer L. Gommerman¹, Koroboshka Brand-Arzamendi², Raphael Schneider²^,⁴, Shannon E Dunn¹^,²^,⁵

¹Department of Immunology, University of Toronto, ²Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, ³Sickkids Research Institute, The Hospital for Sick Children, ⁴BARLO MS Centre, St. Michael’s Hospital, ⁵Women’s College Research Institute, Women’s College Hospital

Podsumowanie

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Central Nervous System

Autoimmune Encephalomyelitis

Experimental Autoimmune Encephalomyelitis

Multiple Sclerosis

MS Risk Factors

Brain Inflammation

Immune Infiltration

Neurofilament Light

Rozdziały w tym wideo

0:00

Introduction

1:48

Harvesting and Fixing Mouse Brain and Spinal Cord Tissues for Histological Scoring of Experimental Autoimmune Encephalomyelitis

3:15

Paraffin Embedding and Histopathological Scoring of Demyelinating Lesions and Perivascular Cuffs in Mouse Brain and Spinal Cord Tissues

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