Erik D. Roberson

Contemporary approaches to Alzheimer's disease and frontotemporal dementia.

Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling.

Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Geriatric epilepsy: research and clinical directions for the future.

Mouse models of Alzheimer's disease.

Challenges and opportunities for characterizing cognitive aging across species.

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.

Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent Deficits.

Mouse models of frontotemporal dementia.

Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease.

Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.

The dendritic hypothesis for Alzheimer's disease pathophysiology.

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.

Seizure resistance without parkinsonism in aged mice after tau reduction.

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.

AlphaScreen HTS and live-cell bioluminescence resonance energy transfer (BRET) assays for identification of Tau-Fyn SH3 interaction inhibitors for Alzheimer disease.

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia.

DNA methylation slows effects of C9orf72 mutations: An epigenetic brake on genetic inheritance.

Tau-dependent kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease.

Noradrenergic dysfunction in Alzheimer's disease.

The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity.

Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice.

Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer's disease.

Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.

Incidence and impact of subclinical epileptiform activity in Alzheimer's disease.

Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer's disease.

Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study.

Genetic influences on cognition in progressive supranuclear palsy.

Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.

Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging.

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.

Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.

Medical decision-making in progressive supranuclear palsy: A comparison to other neurodegenerative disorders.

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies.

Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration.

Biomarker Localization, Analysis, Visualization, Extraction, and Registration (BLAzER) Methodology for Research and Clinical Brain PET Applications.

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity.

Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial.

Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration.

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau.

Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles.

Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.

Nonlinear Z-score modeling for improved detection of cognitive abnormality.

Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases.

Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade.

Neurodegenerative Disease-Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain.

Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases.

Alzheimer's disease risk gene induces Tau-dependent network hyperexcitability.

Functional insights from biophysical study of TREM2 interactions with apoE and Aβ.

Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients.

A REDCap-based model for electronic consent (eConsent): Moving toward a more personalized consent.

Brain volumetric deficits in MAPT mutation carriers: a multisite study.

Racial Differences in Alzheimer's Disease Specialist Encounters Are Associated with Usage of Molecular Imaging and Dementia Medications: An Enterprise-Wide Analysis Using i2b2.

Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.

Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration.

Templated α-Synuclein Inclusion Formation Is Independent of Endogenous Tau.

Dynamic Amyloid PET: Relationships to F-Flortaucipir Tau PET Measures.

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.

Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice.

Development of a multi-component intervention to promote participation of Black and Latinx individuals in biomedical research.

Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer's Mice.

Influence of Subject-Specific Effects in Longitudinal Modelling of Cognitive Decline in Alzheimer's Disease.

TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model.

Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders.

14-3-3θ Does Not Protect against Behavioral or Pathological Deficits in Alzheimer's Disease Mouse Models.

Association of Performance on the Financial Capacity Instrument-Short Form With Brain Amyloid Load and Cortical Thickness in Older Adults.

Differences in Motor Features of , , or Variant Carriers With Familial Frontotemporal Lobar Degeneration.

Development and implementation of an electronic Clinical Dementia Rating and Financial Capacity Instrument-Short Form.

Temporal order of clinical and biomarker changes in familial frontotemporal dementia.

Item Response Analysis of the Financial Capacity Instrument-Short Form.

Preclinical Interventions in Mouse Models of Frontotemporal Dementia Due to Progranulin Mutations.

Contributions of rare and common variation to early-onset and atypical dementia risk.

Longitudinal head-to-head comparison of C-PiB and F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer's disease.

Contributions of rare and common variation to early-onset and atypical dementia risk.

Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia.

Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum.

Evaluation of the Electronic Clinical Dementia Rating for Dementia Screening.

Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White Individuals.

Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability.

Gene specific effects on brain volume and cognition of in frontotemporal lobar degeneration.

Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial.

Quantifying Putative Retinal Gliosis in Preclinical Alzheimer's Disease.

Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals.

Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants.

Gene-Specific Effects on Brain Volume and Cognition of in Frontotemporal Lobar Degeneration.

Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models.

Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia.

Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders.

Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia.

Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.

Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease.