Division of Molecular Biology and Human Genetics,
SAMRC Centre for TB Research,
DSI-NRF Centre of Excellence for Biomedical TB Research,
Department of Biomedical Sciences,
Faculty of Medicine and Health Sciences,
Division of Molecular Biology and Human Genetics, SAMRC Centre for TB Research, DSI-NRF Centre of Excellence for Biomedical TB Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences
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Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa.
Emerging infectious diseases Mar, 2013 | Pubmed ID: 23622714
Whole genome sequencing reveals genomic heterogeneity and antibiotic purification in Mycobacterium tuberculosis isolates.
BMC genomics Oct, 2015 | Pubmed ID: 26496891
Whole genome sequence analysis of Mycobacterium suricattae.
Tuberculosis (Edinburgh, Scotland) Dec, 2015 | Pubmed ID: 26542221
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages.
BMC genomics Feb, 2016 | Pubmed ID: 26923687
The plasmid-mediated evolution of the mycobacterial ESX (Type VII) secretion systems.
BMC evolutionary biology Mar, 2016 | Pubmed ID: 26979252
Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) Jul, 2016 | Pubmed ID: 27450014
Implementation of new tools for multidrug-resistant tuberculosis detection and control.
International journal of mycobacteriology Dec, 2016 | Pubmed ID: 28043620
Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases Jul, 2017 | Pubmed ID: 28412523
Exploring the potential of T7 bacteriophage protein Gp2 as a novel inhibitor of mycobacterial RNA polymerase.
Tuberculosis (Edinburgh, Scotland) Sep, 2017 | Pubmed ID: 28802409
Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique.
PLoS neglected tropical diseases Jan, 2018 | Pubmed ID: 29346413
Papanicolaou induced fluorescence, Ziehl-Neelsen and Auramine O stains on lymph node fine needle aspiration biopsy specimens from children: A comparative study.
Diagnostic cytopathology Jul, 2018 | Pubmed ID: 29722172
Accuracy of whole genome sequencing versus phenotypic (MGIT) and commercial molecular tests for detection of drug-resistant Mycobacterium tuberculosis isolated from patients in Brazil and Mozambique.
Tuberculosis (Edinburgh, Scotland) May, 2018 | Pubmed ID: 29779775
IP-10: A potential biomarker for detection of Mycobacterium bovis infection in warthogs (Phacochoerus africanus).
Veterinary immunology and immunopathology Jul, 2018 | Pubmed ID: 29914681
Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug-Resistant Tuberculosis.
Journal of clinical microbiology Sep, 2018 | Pubmed ID: 29976588
Parallel testing increases detection of Mycobacterium bovis-infected African buffaloes (Syncerus caffer).
Veterinary immunology and immunopathology Oct, 2018 | Pubmed ID: 30596379
Deciphering Within-Host Microevolution of through Whole-Genome Sequencing: the Phenotypic Impact and Way Forward.
Microbiology and molecular biology reviews : MMBR May, 2019 | Pubmed ID: 30918049
Recovery of from positive mycobacterium growth indicator tubes stored at room temperature for up to 6 years in low-income and High-Tuberculosis-Burden Country.
International journal of mycobacteriology , 2019 | Pubmed ID: 31210164
On the Impact of the Pangenome and Annotation Discrepancies While Building Protein Sequence Databases for Bacteria Proteogenomics.
Frontiers in microbiology , 2019 | Pubmed ID: 31281302
Parallel measurement of IFN-γ and IP-10 in QuantiFERON®-TB Gold (QFT) plasma improves the detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).
Preventive veterinary medicine Aug, 2019 | Pubmed ID: 31311648
Xpert MTB/RIF performance to diagnose tuberculosis and rifampicin resistance in a reference centre in southern Brazil.
ERJ open research Jul, 2019 | Pubmed ID: 31404338
Distinct serum biosignatures are associated with different tuberculosis treatment outcomes.
Tuberculosis (Edinburgh, Scotland) Sep, 2019 | Pubmed ID: 31434026
Impact of Mycobacterium bovis-induced pathology on interpretation of QuantiFERON®-TB Gold assay results in African buffaloes (Syncerus caffer).
Veterinary immunology and immunopathology Nov, 2019 | Pubmed ID: 31470250
Detection of Second Line Drug Resistance among Drug Resistant Mycobacterium Tuberculosis Isolates in Botswana.
Pathogens (Basel, Switzerland) Oct, 2019 | Pubmed ID: 31661825
A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic.
BMC medicine Feb, 2020 | Pubmed ID: 32014024
Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique.
Tuberculosis (Edinburgh, Scotland) Mar, 2020 | Pubmed ID: 32063558
Tuberculosis research in South Africa over the past 30 years: From bench to bedside.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde Dec, 2019 | Pubmed ID: 32252868
Molecular epidemiology of drug resistant Mycobacterium tuberculosis in Africa: a systematic review.
BMC infectious diseases May, 2020 | Pubmed ID: 32404119
Genetic Diversity in Clinical Isolates and Resulting Outcomes of Tuberculosis Infection and Disease.
Annual review of genetics Nov, 2020 | Pubmed ID: 32926793
COVID-19 cough classification using machine learning and global smartphone recordings.
Computers in biology and medicine Aug, 2021 | Pubmed ID: 34182331
COVID-19 detection in cough, breath and speech using deep transfer learning and bottleneck features.
Computers in biology and medicine Feb, 2022 | Pubmed ID: 34954610
New insights on tuberculosis transmission dynamics and drug susceptibility profiles among the prison population in Southern Brazil based on whole-genome sequencing.
Revista da Sociedade Brasileira de Medicina Tropical , 2023 | Pubmed ID: 36820651
Comparison of two diagnostic intervention packages for community-based active case finding for tuberculosis: an open-label randomized controlled trial.
Nature medicine Apr, 2023 | Pubmed ID: 36894651
Integrating molecular and radiological screening tools during community-based active case-finding for tuberculosis and COVID-19 in southern Africa.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Aug, 2024 | Pubmed ID: 38701914
Exploring the potential of Oxford Nanopore Technologies sequencing for Mycobacterium tuberculosis sequencing: An assessment of R10 flowcells and V14 chemistry.
PloS one , 2024 | Pubmed ID: 38843147
A Genome-Focused Investigation Reveals the Emergence of a Strain Related to Multidrug-Resistant Tuberculosis in the Amazon Region of Brazil.
Microorganisms Sep, 2024 | Pubmed ID: 39338491
Comprehensive genomic surveillance reveals transmission profiles of extensively drug-resistant tuberculosis cases in Pará, Brazil.
Frontiers in microbiology , 2024 | Pubmed ID: 39911713
Jennifer Williams*,1,
Janré Steyn*,1,
Emilyn Costa Conceição*,1,
Felicia Bernita Wells1,
Melanie Grobbelaar1,
Nabila Ismail1,
Yonas Ghebrekristos1,2,
Christoffel Johannes Opperman1,2,3,4,
Sarishna Singh1,2,
Jason Limberis5,
Fahd Naufal5,
Brendon Coenrad Mann1,
Rebecca E. Colman6,7,
Timothy Rodwell*,6,7,
Robin Mark Warren*,1,
John Z. Metcalfe*,5
1Division of Molecular Biology and Human Genetics, SAMRC Centre for TB Research, DSI-NRF Centre of Excellence for Biomedical TB Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University,
2National Health Laboratory Service, Green Point Tuberculosis Laboratory,
3Division of Medical Microbiology, Department of Pathology, University of Cape Town,
4Division of Medical Microbiology, Department of Pathology, University of Cape Town,
5Division of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General Hospital and Trauma Centre, University of California, San Francisco,
6Department of Medicine, University of California, San Diego, School of Medicine,
7Foundation for Innovative New Diagnostics (FIND), Campus Biotech
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