Chapter 40
A Hierarchical Stem-Cell System: Blood Cell Formation
Panoramica del sistema vascolare
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and ...
Meccanismo dell'angiogenesi
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called ...
Regolazione dell'angiogenesi e dell'afflusso di sangue
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or ...
Ematopoiesi
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This ...
Multipotenza delle cellule staminali ematopoietiche
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in ...
Impegno di derivazione
Commitment is the process whereby stem cells:
lose their ability to form all cell types and
irreversibly change into a specific type.
The ...
Eritropoiesi
Red blood cells (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis ...
Differenziazione delle cellule progenitrici mieloidi comuni
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are ...
Regolazione delle cellule staminali ematopoietiche
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a ...
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