Génération d'agrégats de souris de cellules souches embryonnaires qui montrent la brisure de symétrie, la polarisation et le comportement collectif émergent

We have developed a protocol to generate aggregates of mouse embryonic stem cells that display self-organization, symmetry breaking and elongation paralleling axial development. This technique allows the study of axial developmental processes and the generation of cell types that are otherwise difficult to perform in monolayer culture.