Chapter 15
Mass Spectrometry Fragmentation Methods
Spectrométrie de masse: fragmentation des alcanes à longue chaîne
The molecular ions of linear alkanes prefer to fragment at the carbon-carbon bond away from the end of the chain since the cleavage of an inner bond ...
Spectrométrie de masse : fragmentation d’alcanes ramifiés
This lesson delves into the mass spectrometry of branched alkane fragmentation. Branched alkanes possess secondary or tertiary carbon atoms, which ...
Spectrométrie de masse : fragmentation des cycloalcanes
In mass spectrometry, cycloalkanes exhibit distinct fragmentation patterns due to the inherent stability of their molecular ions compared to linear or ...
Spectrométrie de masse: fragmentation des alcènes
Alkenes lose one electron from the unsaturated π bond upon ionization and form stable molecular ions. Further fragmentation of alkenes occurs through ...
Spectrométrie de masse : fragmentation des cycloalcènes
The molecular ions of cycloalkenes undergo fragmentation via a retro-Diels–Alder reaction.
The reaction proceeds via the cleavage of two ...
Spectrométrie de masse: fragmentation des alcynes
The fragmentation of alkynes preferentially occurs at the carbon–carbon bond between the α and β carbon of the alkyne bond to generate a ...
Spectrométrie de masse: fragmentation de l'alcool
Alcohols (R-OH) ionize to lose one non-bonded electron from the oxygen atom, forming molecular ions. Due to their tendency to fragment rapidly, the ...
Spectrométrie de masse: fragmentation des composés aromatiques
Upon ionization, aromatic compounds generate a molecular ion that is observed as a prominent peak in their mass spectra. For example, the molecular ion ...
Spectrométrie de masse: fragmentation des amines
Amines can be identified using mass spectroscopy based on their characteristic fragmentation patterns. The molecular ions of amines undergo fragmentation ...
Mass Spectrometry: Alkyl Halide Fragmentation
Chlorine isotopes exist as 35Cl and 37Cl in a 3:1 ratio, while bromine isotopes exist as 79Br and 81Br in a 1:1 ratio. The mass spectrum of alkyl halides ...
Spectrométrie de masse: fragmentation des aldéhydes et des cétones
In mass spectrometry, the fragmentation of aliphatic aldehydes and ketones generally occurs through three key mechanisms: α-cleavage, inductive ...
Spectrométrie de masse : fragmentation des acides carboxyliques, des esters et des amides
The fragmentation patterns observed for compounds such as carboxylic acids, esters, and amides in the mass spectra include ⍺-cleavage and McLafferty ...
Spectrométrie de masse à ionisation chimique (CI)
The molecular ion peak of a molecule in the mass spectrum provides vital information for molecular identification. However, conventional electron impact ...
Spectrométrie de masse par ionisation par électrospray (ESI)
Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional ...
Désorption-ionisation laser assistée par matrice (MALDI)
Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and ...
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