Division of Nephrology and Hypertension,
Department of Medicine,
Division of Nephrology and Hypertension, Department of Medicine
Dr. Kensei Taguchi is a postdoctoral research fellow in Division of Nephrology and Hypertension, Vanderbilt University Medical Center in Nashville, Tennessee. He received a M.D. degree from Kurume University School of Medicine of Japan in 2006 and a Ph.D. from Kurume University Graduate school.
During his clinical practice, Dr. Taguchi saw many of the patients develop complications due to dialysis and felt there had to be a better solution. Then, he started pursing a PhD with the hopes of finding new treatment options that can be translated from bench to bedside. While he was in graduate school, he studied the pathological role of receptor for advanced glycation endproducts (RAGE) in diabetic and hypertensive nephropathy. He also created DNA aptamer directed against RAGE which can block the interaction of ligands and RAGE and confirmed its inhibitory efficacy. During a postdoctoral training in Vanderbilt, Nashville, Tennessee, he utilized super resolution microscopy to investigate the morphological changes of mitochondrial following kidney injury. In addition, he has been engaged in investigating the mechanism of how acute kidney injury predisposes patients to chronic injury. Dr. Taguchi received a research fund from American Heart Association (2020-2021).
RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice.
Scientific reports 02, 2018 | Pubmed ID: 29422652
Cyclin G1 and TASCC regulate kidney epithelial cell G-M arrest and fibrotic maladaptive repair.
Science translational medicine 01, 2019 | Pubmed ID: 30674655
TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance.
JCI insight 03, 2019 | Pubmed ID: 30870143
Quantifying autophagic flux in kidney tissue using structured illumination microscopy.
Methods in cell biology , 2019 | Pubmed ID: 31395381
Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses.
The Journal of clinical investigation 11, 2019 | Pubmed ID: 31589169
Uremic Toxin-Targeting as a Therapeutic Strategy for Preventing Cardiorenal Syndrome.
Circulation journal : official journal of the Japanese Circulation Society 12, 2019 | Pubmed ID: 31827008
Kidney epithelial targeted mitochondrial transcription factor A deficiency results in progressive mitochondrial depletion associated with severe cystic disease.
Kidney international 03, 2021 | Pubmed ID: 33159962
Dual disruption of eNOS and ApoE gene accelerates kidney fibrosis and senescence after injury.
Biochemical and biophysical research communications 06, 2021 | Pubmed ID: 33845306
Dysbiosis-Related Advanced Glycation Endproducts and Trimethylamine N-Oxide in Chronic Kidney Disease.
Toxins 05, 2021 | Pubmed ID: 34069405
版权所属 © 2025 MyJoVE 公司版权所有,本公司不涉及任何医疗业务和医疗服务。