Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
11.9K Views
•
07:32 min
•
May 6th, 2020
DOI :
May 6th, 2020
•William J. Pinamont1, Natalie K. Yoshioka1, Gregory M. Young1, Vengadeshprabhu Karuppagounder1, Elijah L. Carlson1, Adeel Ahmad1, Reyad Elbarbary1,2, Fadia Kamal1,3
1Center for Orthopedic Research and Translational Sciences, Department of Orthopedics and Rehabilitation, Pennsylvania State College of Medicine, 2Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine, 3Department of Pharmacology, Pennsylvania State College of Medicine
Chapters in this video
0:04
Introduction
1:13
Histomorphometric Analysis Setup
1:59
Total, Calcified, and Uncalcified Cartilage Area Measurements
2:47
Chondrocyte Number and Phenotype Evaluation
3:17
Tibial Articular Surface Perimeter Measurement
3:47
Subchondral Bone and Marrow Space Area Measurement
4:30
Anterior and Posterior Osteophyte Area and Synovial Thickness Measurement
5:21
Results: Representative Histomorphometric Osteoarthritis (OA) Evaluation in Destabilization of the Medial Meniscus (DMM) and Sham Mice
7:06
Conclusion
Related Videos
07:58
Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis
27.5K Views
08:42
Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants
6.8K Views
09:26
The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse
34.8K Views
08:17
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
16.2K Views
06:41
A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
8.2K Views
12:23
Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
19.3K Views
08:52
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
2.9K Views
07:06
Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
4.2K Views
05:50
Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
1.0K Views
06:59
Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
2.1K Views
Copyright © 2025 MyJoVE Corporation. All rights reserved