1.6 : 薬物動態学における基本的な数学的原理: 数式と単位

Mathematical expressions help understand pharmacokinetic parameters by using equations to describe the relationships between different variables.

For instance, exponential functions describe drug elimination, exemplified by the equation for drug concentration C at a given time t, where C₀ denotes the initial concentration and k represents the elimination rate constant.

Valid equations entail consistent integers and units or dimensions on both sides.

Logarithmic functions, such as the pH of biological fluids, aid in understanding the pharmacokinetic profiles of drugs, such as the degree of ionization in vivo.

Pharmacokinetics employs a diverse range of units. For instance, drug concentration, a critical factor for dosing and therapeutic monitoring, is commonly expressed using units like mg/L, μg/mL, and ng/mL.

Significant figures imply the number of accurate digits in a measurement. For instance, a measured drug concentration of 2.35 μg/mL reflects higher accuracy than 2 μg/mL.